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phenobarbital raises toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. CYP3A4 inducers might increase the metabolism of ifosfamide to its Lively alkylating metabolites.Keep away from; coadministration with CYP3A inducers may possibly result in diminished plasma concentrations of elvitegravir and/or